This is an academic paper that gives an overview of studies that have examined the association between socioeconomic characteristics and opioid-related overdose deaths. Nearly all reviewed studies found a connection between a socioeconomic variable and overdose, supporting the Deaths of Despair hypothesis.
van Draanen, J., Tsang, C., Mitra, S., Karamouzian, M., Richardson, L. (2020). Socioeconomic marginalization and opioid-related overdose: A systematic review. Drug and Alcohol Dependence, 214, 108127.