This study sought to understand important changes in co-occurring opioid and nonopioid drug use (i.e., polysubstance use) within the opioid crisis in the United States. Past-month use of at least 1 nonopioid drug occurred in nearly all participants (> 90%) in this study.

This paper emphasizes that viewing opioid trends in a “silo” ignores the fact that polysubstance use is ubiquitous among those with opioid use disorder and that significant changes in polysubstance use should be monitored alongside opioid trends.