This is an academic paper that found that prescription opioid pill counts were higher for individuals in rural areas, suggesting that interventions tailored to drug safety and disposal, such as lock boxes and prescription drop-off boxes, may be more effective in rural areas.
Lee, W.C., Hutchison, R.W., Lin, S., Kuo, Y.F. (2020). Patient Education on Opioid Storage, Security, and Disposal of Opioids: Should the Approach Differ in Rural and Urban Settings? Texas Journal of Health System Pharmacists, 19(1), 46-51