This is a manual created by the Harm Reduction Coalition that is designed to outline the process of developing and managing an Overdose Prevention and Education Program (OPEP), with or without a take-home naloxone component. It offers practical suggestions and considerations rooted in harm reduction - an approach to drug use that promotes and honors the competence of drug users to protect themselves, their loved ones, and their communities and the belief that drug users have a right to respect, health, and access to life-saving tools and information. There are several case studies of existing harm reduction program models.