The opioid overdose crisis requires efficient targeting of overdose prevention resources. In collaboration with the Illinois Statewide Unintentional Drug Overdose Reporting System (SUDORS) at the Northwestern University Feinberg School of Medicine, Buehler Center for Health Policy & Economics, the Block by Block initiative identifies hotspots in areas with high concentrations of opioid overdose deaths. It recruits residents and organizations living or working in those areas to take part in naloxone training to identify signs of overdose, administer naloxone, and provide resources for treatment and support services as well as how to use fentanyl test strips. Participants who complete the training are given naloxone and fentanyl test strip kits, resource materials for handing out, and window and yard signs alerting passersby that someone with naloxone administration training lives or works in the building. Program participants go door to door to distribute materials, educate community members, and encourage others to participate in the initiative. 

A project manual for Block by Block describes its objectives and implementation procedures, and a process evaluation found it to be successful in distributing materials and in recruiting community residents. Contact information for Block by Block can be found at the project website.