This is a statistical brief from the Healthcare Cost and Utilization Project (HCUP) that describes how counties that have high versus low population rates of opioid-related hospital use differ with regard to social determinants of health (SDOH). The SDOH studied include social, educational, and economic characteristics; physical infrastructure; and healthcare characteristics. Results show that counties with high population rates of opioid-related hospital use have a meaningfully different SDOH profile.