This report from the CDC analyzes Illicit drug use and drug use disorders during 2003–2014, and drug overdose deaths during 1999–2015 by metropolitan versus nonmetropolitan areas.
Mack, K.A., Jones, C.M., Ballesteros, M.F. (2017). Illicit Drug Use, Illicit Drug Use Disorders, and Drug Overdose Deaths in Metropolitan and Nonmetropolitan Areas — United States. MMWR Surveill Summ, 66(No. SS-19), 1–12.